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Publication Date



These guidelines do not establish a standard of care to be followed in every case. It is recognized that each case is different and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare guidelines for each. Accordingly, these guidelines should guide care with the understanding that departures from them may be required at times.

Objective of the Guideline

The objective of this CPG is to improve and standardize the care of children with newly diagnosed and newly relapsed malignancies at risk of tumor lysis syndrome (TLS).

Target Users

Emergency Medicine, Urgent Care, Pediatric Intensive Care and Oncology providers; Oncology Fellows; House Staff; Pediatric Nurse Practitioners

Tumor Lysis Syndrome (TLS)