Document Type

Article

Publication Date

4-1-2017

Identifier

MCID: PMC5365720 DOI: 10.1128/AAC.02014-16

Abstract

Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from three separate trials. A total of 420 samples from 220 children, 76 of whom had a body mass index greater than or equal to the 95th percentile for age, were included in the analysis. Compared to other metrics, total body weight (TBW) was the most robust measure of body size. The final model included TBW and a sigmoidal maturation relationship between postmenstrual age (PMA) and clearance (CL): CL (liters/hour) = 13.8 × (TBW/70)

Journal Title

Antimicrobial agents and chemotherapy

Volume

61

Issue

4

MeSH Keywords

Adolescent; Anti-Bacterial Agents; Area Under Curve; Bayes Theorem; Biological Availability; Body Mass Index; Body Weight; Child; Clindamycin; Drug Administration Schedule; Drug Dosage Calculations; Female; Humans; Injections, Intravenous; Male; Models, Statistical; Obesity; Orosomucoid; Serum Albumin

Keywords

antibiotics; children; clindamycin; obesity; pharmacokinetics

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