Title

Reversal of hypercalcemic acute kidney injury by treatment with intravenous bisphosphonates.

Document Type

Article

Publication Date

3-1-2009

Identifier

DOI: 10.1007/s00467-008-1011-y

Abstract

We present the details of three children with hypercalcemia-induced acute kidney injury (AKI). After traditional therapy with fluids, loop diuretics, steroids and calcitonin had failed to correct the hypercalcemia, they were given treatment with low doses of intravenous (i.v.) pamidronate, which resulted in normalization of serum calcium and kidney function. In one child Doppler renal ultrasound revealed dampened arterial blood flow, which resolved with normalization of serum calcium. On the basis of cumulative data and our experience, we suggest that i.v. application of bisphosphonates be moved from the second to the first line of treatment of hypercalcemic AKI.

Journal Title

Pediatric nephrology (Berlin, Germany)

Volume

24

Issue

3

First Page

613

Last Page

617

MeSH Keywords

Acute Disease; Adolescent; Bone Density Conservation Agents; Child; Child, Preschool; Diphosphonates; Female; Humans; Hypercalcemia; Injections, Intravenous; Kidney Diseases; Pamidronate

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