Title

Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation.

Document Type

Article

Publication Date

5-1-2019

Identifier

PMCID: PMC6511311 [Available on 2020-05-01] DOI: 10.1016/j.bbmt.2018.11.033

Abstract

Non-graft-versus-host disease (GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. We summarize the incidence, risk factors, screening, prevention, and treatment of individual complications and generate evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical signs and symptoms and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complications after HCT. Both transplantation physicians and ophthalmologists should be knowledgeable about non-GVHD ocular complications and provide comprehensive collaborative team care.

Journal Title

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Volume

25

Issue

5

First Page

145

Last Page

145

MeSH Keywords

Hematopoietic Stem Cell Transplantation; Eye Diseases; Neoplasms/complications

Keywords

Complication; Eye; Hematopoietic cell transplantation; Prevention; Review; Treatment

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Biol Blood Marrow Transplant. 2019 May;25(5):e145-e154. doi: 10.1016/j.bbmt.2018.11.033. Epub 2018 Dec 3.

Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation.

Inamoto Y1, Petriček I2, Burns L3, Chhabra S4, DeFilipp Z5, Hematti P6, Rovó A7, Schears R8, Shah A9, Agrawal V10, Ahmed A11, Ahmed I12, Ali A13, Aljurf M14, Alkhateeb H8, Beitinjaneh A15, Bhatt N16, Buchbinder D17, Byrne M18, Callander N19, Fahnehjelm K20, Farhadfar N21, Gale RP22, Ganguly S23, Hashmi S14, Hildebrandt GC24, Horn E21, Jakubowski A25, Kamble RT26, Law J27, Lee C28, Nathan S29, Penack O30, Pingali R31, Prasad P32, Pulanic D33, Rotz S34, Shreenivas A35, Steinberg A35, Tabbara K36, Tichelli A37, Wirk B38, Yared J39, Basak GW40, Battiwalla M41, Duarte R42, Savani BN18, Flowers MED43, Shaw BE16, Valdés-Sanz N44.

Author information

Abstract

Non-graft-versus-host disease (GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. We summarize the incidence, risk factors, screening, prevention, and treatment of individual complications and generate evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical signs and symptoms and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complications after HCT. Both transplantation physicians and ophthalmologists should be knowledgeable about non-GVHD ocular complications and provide comprehensive collaborative team care.

Copyright © 2018 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Complication; Eye; Hematopoietic cell transplantation; Prevention; Review; Treatment

PMID:
30521975
PMCID:
PMC6511311
[Available on 2020-05-01]
DOI:
10.1016/j.bbmt.2018.11.033
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