Variability of surgical prophylaxis in penicillin-allergic children.
We retrospectively evaluated the effect of penicillin adverse drug reaction (ADR) labeling on surgical antibiotic prophylaxis. Cefazolin was administered in 86% of penicillin ADR-negative (-) and 28% penicillin ADR-positive (+) cases. Broad-spectrum antibiotic use was more common in ADR(+) cases and was more commonly associated with perioperative adverse drug events.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America
Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Child; Child, Preschool; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Electronic Health Records; Female; General Surgery; Humans; Male; Pediatrics; Penicillins; Preoperative Care; Retrospective Studies; Washington
Butler, D. F., Lee, B. R., Suppes, S., Sandritter, T., Newland, J. G., Harte, L., Goldman, J. Variability of surgical prophylaxis in penicillin-allergic children. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 39, 1480-1483 (2018).