Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population-Based Survey.
BACKGROUND: Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants.
METHODS: We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants ≤12 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow-up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA.
RESULTS: A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) >3.5 IU/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12-month telephone follow-up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP.
CONCLUSIONS: The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12-month follow-up, the majority of CMPA infants had become tolerant to CMP.
JPEN. Journal of parenteral and enteral nutrition
Milk Hypersensitivity; Infant; China; Population Health
cow's milk protein allergy; infants; open oral food challenge; population-based survey
Yang, Min; Tan, Meizhen; Wu, Jieling; Chen, Zhuojie; Long, Xiaoling; Zeng, Yongmei; Cai, Huabo; Zhang, Yong; Geng, Lanlan; Xiao, Yulian; Ke, Haijin; Liu, Ying; Rong, Linhui; Fu, Simao; Wang, Hong; Wang, Yuan; Li, Xiaoxiu; Chen, Peiyu; Li, Kelvin; Xie, Jing; Chen, Huan; Li, Huiwen; Wang, Hongli; Li, Ding-You; and Gong, Sitang, "Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population-Based Survey." (2019). Manuscripts, Articles, Book Chapters and Other Papers. 1371.