End-stage kidney disease in infancy: an educational review.
Document Type
Article
Publication Date
2-1-2020
Identifier
DOI: 10.1007/s00467-018-4151-8; PMCID: PMC6529305
Abstract
An increasing number of infants with end-stage kidney disease (ESKD) are surviving and receiving renal replacement therapy (RRT). Unique clinical issues specific to this age group of patients influence their short- and long-term outcomes. This review summarizes current epidemiology, clinical characteristics, ethical dilemmas, management concerns, and outcomes of infants requiring chronic dialysis therapy. Optimal care during infancy requires a multidisciplinary team working closely with the patient's family. Nutritional management, infection prevention, and attention to cardiovascular status are important treatment targets. Although mortality rates remain higher among infants on dialysis compared to older pediatric dialysis patients, outcomes have improved over time. Most importantly, infants who subsequently receive a kidney transplant are now experiencing graft survival rates that are comparable to older pediatric patients.
Journal Title
Pediatric nephrology (Berlin, Germany)
Volume
35
Issue
2
First Page
229
Last Page
240
MeSH Keywords
Kidney Failure, Chronic; Infant; Infant, Newborn; Infant, Newborn, Diseases; Renal Replacement Therapy
Keywords
Chronic hemodialysis; Chronic peritoneal dialysis; Growth; Hemodialysis; Infants; Neonates; Nutrition; Pediatric ESKD; Peritoneal dialysis
Recommended Citation
Sanderson KR, Warady BA. End-stage kidney disease in infancy: an educational review. Pediatr Nephrol. 2020;35(2):229-240. doi:10.1007/s00467-018-4151-8
Comments
Grant support