Title

Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia.

Document Type

Article

Publication Date

3-2014

Identifier

DOI: 10.1038/jp.2013.152; PMCID: PMC7099681

Abstract

OBJECTIVE: Assess the impact of intercurrent respiratory infections in infants(GA).

STUDY DESIGN: A retrospective cohort study of 111 infants bornGA, controlling for bronchopulmonary dysplasia (BPD) severity and assessing pulmonary health over the first year of life through oxygen, diuretic and inhaled steroid use.

RESULT: Regression analysis showed viral infections increased oxygen use (odds ratio (OR) of 15.5 (confidence interval (CI)=3.4, 71.3)). The trend test showed increasing numbers of viral infections were associated with increased oxygen (OR (95% CI)=6.4 (2.3 to 17.4), P=0.0003), diuretic (OR (95% CI)=2.4 (1.1to 5.2), P=0.02) and inhaled steroid use (OR (95% CI)=2.2 (1.003 to 5.2), P=0.049), whereas bacterial infections were not.

CONCLUSION: Viral infections caused more long-term pulmonary morbidity/mortality than bacterial infections on premature lung health, even when controlling for BPD.

Journal Title

Journal of perinatology : official journal of the California Perinatal Association

Volume

34

Issue

3

First Page

223

Last Page

228

MeSH Keywords

Administration, Inhalation; Bacterial Infections; Bronchopulmonary Dysplasia; Diuretics; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Logistic Models; Lung Diseases; Male; Oxygen Inhalation Therapy; Respiratory Tract Infections; Retrospective Studies; Steroids; Virus Diseases

Keywords

Administration, Inhalation; Bacterial Infections; Bronchopulmonary Dysplasia; Diuretics; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Logistic Models; Lung Diseases; Male; Oxygen Inhalation Therapy; Respiratory Tract Infections; Retrospective Studies; Steroids; Virus Diseases

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