Title

Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.

Document Type

Article

Publication Date

12-2019

Identifier

DOI: 10.1016/j.clp.2019.08.004

Abstract

In this review of analgesic and sedation medication in neonates, important classes of old and newer medications commonly used in the neonatal intensive care unit setting are discussed. In addition to drug metabolism, efficacy, and safety for individual drugs, new insights into multimodal analgesic approaches suggest ways in which multiple analgesic drug classes can be combined to maximize efficacy and minimize toxicity. Opiate pharmacogenetics and the potential for a precision therapeutics approach is explored, with a final description of gaps in knowledge and a call for future research of pain and sedation control in the neonatal population.

Journal Title

Clinics in perinatology

Volume

46

Issue

4

First Page

673

Last Page

692

Keywords

Analgesia; Neonatal; Pain; Pharmacology; Sedation

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