Second Reported Case of Pediatric Bladder Alveolar Soft Part Sarcoma as Secondary Malignancy After Prior Cytotoxic Chemotherapy.
Alveolar soft part sarcoma (ASPS) is a rare malignancy with high rates of metastasis at presentation, defined by an unclear cellular origin and a unique unbalanced ASPSCR1-TFE3 translocation (der(17)t(X:17)(p11:q25)).1 ASPS is insensitive to chemotherapy and has been reported to involve the bladder only twice in the pediatric literature; once as a primary malignancy,2 and once as a secondary malignancy after cytotoxic chemotherapy.3 Herein, we report the third case of pediatric bladder ASPS in a female patient who received cytotoxic chemotherapy for low-risk neuroblastoma. This would represent the second case of pediatric bladder ASPS as a secondary malignancy after prior chemotherapy.
Antineoplastic Agents; Female; Humans; Male; Neoplasms, Second Primary; Neuroblastoma; Sarcoma, Alveolar Soft Part; Urinary Bladder Neoplasms
Antineoplastic Agents; Neoplasms, Second Primary; Neuroblastoma; Sarcoma, Alveolar Soft Part; Urinary Bladder Neoplasms
Penticuff, J., McDermott, S., Carrasco, A., Bowlin, P. R., Lewing, K., Koenig, J. Second Reported Case of Pediatric Bladder Alveolar Soft Part Sarcoma as Secondary Malignancy After Prior Cytotoxic Chemotherapy. Urology 130, 148-150 (2019).