A Novel Perspective on the Biology of Bilirubin in Health and Disease.
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver dysfunction, recent data strongly indicate that mildly elevated bilirubin (BLB) levels can be protective against an array of diseases associated with increased oxidative stress. These clinical observations are supported by new discoveries relating to the role of BLB in immunosuppression and inhibition of protein phosphorylation, resulting in the modulation of intracellular signaling pathways in vascular biology and cancer, among others. Collectively, the evidence suggests that targeting BLB metabolism could be considered a potential therapeutic approach to ameliorate a variety of conditions.
Trends in molecular medicine
Animals; Antioxidants; Bilirubin; Cardiovascular Diseases; Diabetes Mellitus; Humans; Hyperbilirubinemia; Inflammation; Neoplasms; Nervous System Diseases; Oxidation-Reduction; Oxidative Stress; Signal Transduction
bilirubin; bilirubinomics; human health; intracellular events; redox state
Gazzin, S., Vitek, L., Watchko, J., Shapiro, S., Tiribelli, C. A Novel Perspective on the Biology of Bilirubin in Health and Disease. Trends in molecular medicine 22, 758-768 (2016).