Title

A Novel Perspective on the Biology of Bilirubin in Health and Disease.

Document Type

Article

Publication Date

9-2016

Identifier

DOI: 10.1016/j.molmed.2016.07.004

Abstract

Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver dysfunction, recent data strongly indicate that mildly elevated bilirubin (BLB) levels can be protective against an array of diseases associated with increased oxidative stress. These clinical observations are supported by new discoveries relating to the role of BLB in immunosuppression and inhibition of protein phosphorylation, resulting in the modulation of intracellular signaling pathways in vascular biology and cancer, among others. Collectively, the evidence suggests that targeting BLB metabolism could be considered a potential therapeutic approach to ameliorate a variety of conditions.

Journal Title

Trends in molecular medicine

Volume

22

Issue

9

First Page

758

Last Page

768

MeSH Keywords

Animals; Antioxidants; Bilirubin; Cardiovascular Diseases; Diabetes Mellitus; Humans; Hyperbilirubinemia; Inflammation; Neoplasms; Nervous System Diseases; Oxidation-Reduction; Oxidative Stress; Signal Transduction

Keywords

bilirubin; bilirubinomics; human health; intracellular events; redox state

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