Title

Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

Document Type

Article

Publication Date

10-15-2014

Identifier

DOI: 10.1093/infdis/jiu245; PMCID: PMC4271072

Abstract

© The Author 2014. Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

Journal Title

Journal of Infectious Diseases

Volume

210

Issue

8

First Page

1270

Last Page

1274

Keywords

Body mass index; Immune response; Influenza vaccine; Obesity

Share

COinS