Overcoming resistance to immunotherapy by teaching old drugs new tricks.
Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses of doxorubicin can target CSCs by restoring anticancer immunity.
Mol Cell Oncol
Akt; Cancer stem cells; Wnt; chemoresistance; immune checkpoints; immune escape; immune privilege; immunosurveillance; β-catenin
Perry, J. M., Li, L. Overcoming resistance to immunotherapy by teaching old drugs new tricks. Mol Cell Oncol 7, 1801088-1801088 (2020).