Title

Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.

Document Type

Article

Publication Date

6-1-2020

Identifier

DOI: 10.1016/j.jpeds.2020.01.032

Abstract

Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.

Journal Title

The Journal of pediatrics

Volume

221

First Page

235

Last Page

239

Keywords

Down syndrome; folates; pediatrics; precision medicine; toxicity

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