Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.
Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.
The Journal of pediatrics
Down syndrome; folates; pediatrics; precision medicine; toxicity
Funk RS, Talib NJ, Zimmerman KO, van Haandel L, Becker ML. Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity. J Pediatr. 2020;221:235-239. doi:10.1016/j.jpeds.2020.01.032