Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.
Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.
The Journal of pediatrics
Down syndrome; folates; pediatrics; precision medicine; toxicity
Funk, R. S., Talib, N., Zimmerman, K. O., van Haandel, L., Becker, M. L. Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity. The Journal of pediatrics 221, 235-239 (2020).