Colostomy in children on chronic peritoneal dialysis.
BACKGROUND: This study aimed to evaluate outcome of children on chronic peritoneal dialysis (PD) with a concurrent colostomy.
METHODS: Patients were identified through the International Pediatric Peritoneal Dialysis Network (IPPN) registry. Matched controls were randomly selected from the registry. Data were collected through the IPPN database and a survey disseminated to all participating sites.
RESULTS: Fifteen centers reported 20 children who received chronic PD with a co-existing colostomy. The most common cause of end stage kidney disease was congenital anomalies of the kidney and urinary tract (n = 16, 80%). The main reason for colostomy placement was anorectal malformation (n = 13, 65%). The median age at colostomy creation and PD catheter (PDC) insertion were 0.1 (IQR, 0-2.2) and 2.8 (IQR 0.2-18.8) months, respectively. The colostomies and PDCs were present together for a median 18 (IQR, 4.9-35.8) months. The median age at PDC placement in 46 controls was 3.4 (IQR, 0.2-7.4) months of age. Fourteen patients (70%) developed 39 episodes of peritonitis. The annualized peritonitis rate was significantly higher in the colostomy group (1.13 vs. 0.70 episodes per patient year; p = 0.02). Predominant causative microorganisms were Staphylococcus aureus (15%) and Pseudomonas aeruginosa (13%). There were 12 exit site infection (ESI) episodes reported exclusively in colostomy patients. Seven colostomy children (35%) died during their course of PD, in two cases due to peritonitis.
CONCLUSION: Although feasible in children with a colostomy, chronic PD is associated with an increased risk of peritonitis and mortality. Continued efforts to reduce infection risk for this complex patient population are essential.
Pediatric nephrology (Berlin, Germany)
Children; Colostomy; Exit site infection; Ostomy; Peritoneal dialysis; Peritonitis
Chan, E. Y., Borzych-Duzalka, D., Alparslan, C., Harvey, E., Munarriz, R., Runowski, D., Vidal, E., Coccia, P. A., Jankauskiene, A., Principi, I., Serdaroglu, E., Szczepanska, M., Tse, Y., Vazquez, A., Weaver, D. J., Schaefer, F., Warady, B. A., . Colostomy in children on chronic peritoneal dialysis. Pediatric nephrology (Berlin, Germany) 35, 119-126 (2020).