Title

Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Document Type

Article

Publication Date

11-2019

Identifier

DOI: 10.1007/s00467-019-04319-2

Abstract

BACKGROUND: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT).

METHODS: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed.

RESULTS AND CONCLUSIONS: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.

Journal Title

Pediatric nephrology (Berlin, Germany)

Volume

34

Issue

11

First Page

2427

Last Page

2448

MeSH Keywords

Acute Kidney Injury; Adolescent; Child; Child, Preschool; Consensus; Consensus Development Conferences as Topic; Female; Humans; Infant; Male; Nephrology; Poisoning; Practice Guidelines as Topic; Renal Replacement Therapy; Young Adult

Keywords

Children; Hemodialysis; Intoxications; Renal replacement therapies

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