Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.
Document Type
Article
Publication Date
11-2019
Identifier
DOI: 10.1007/s00467-019-04319-2
Abstract
BACKGROUND: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT).
METHODS: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed.
RESULTS AND CONCLUSIONS: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.
Journal Title
Pediatric nephrology (Berlin, Germany)
Volume
34
Issue
11
First Page
2427
Last Page
2448
MeSH Keywords
Acute Kidney Injury; Adolescent; Child; Child, Preschool; Consensus; Consensus Development Conferences as Topic; Female; Humans; Infant; Male; Nephrology; Poisoning; Practice Guidelines as Topic; Renal Replacement Therapy; Young Adult
Keywords
Children; Hemodialysis; Intoxications; Renal replacement therapies
Recommended Citation
Raina R, Grewal MK, Blackford M, et al. Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup. Pediatr Nephrol. 2019;34(11):2427-2448. doi:10.1007/s00467-019-04319-2
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