Patient Carrying Time, Confidence, and Training with Epinephrine Autoinjectors: The RACE Survey.
BACKGROUND: Limited real-world data exist regarding patient carrying compliance and confidence in using different types of epinephrine autoinjectors (EAIs).
OBJECTIVE: To perform a Real-world Assessment of Patients' Carrying Time and Confidence with Epinephrine Autoinjector Devices (RACE survey).
METHODS: This was a noninterventional survey of patients (≥7 years) who filled 1 or more prescription for Auvi-Q or EpiPen between January 2013 and January 2014. Outcomes included proportion of patients carrying their EAI all the time in the last 7 days (primary), EAI use confidence (secondary), and EAI training experience (secondary). Multivariate regression analyses controlled for significant differences in demographic and clinical characteristics between EAI groups.
RESULTS: The survey included 2,000 participants (Auvi-Q, N = 1,000 [children, n = 597; adults, n = 403]; EpiPen, N = 1,000 [children, n = 105; adults, n = 895]). After adjusting for confounding factors, we found that Auvi-Q respondents were more likely to carry their device all the time in the last 7 days versus EpiPen respondents (adjusted odds ratio [aOR], 1.91; 95% CI, 1.49-2.45; P < .001); similar trends were observed in adults and children (P < .001 both). Adults in the Auvi-Q group were more likely to feel "very confident" about correctly using their EAI (aOR, 2.02) and someone else correctly using their EAI (aOR, 2.25) versus the EpiPen group (P < .001 both). Compared with EpiPen respondents, Auvi-Q respondents were more likely to feel that EAI instructions were "very clear" (aOR, 3.10) and more likely to find the prescription pack trainer helpful (aOR, 2.29; P < .01 both).
CONCLUSIONS: This study suggests significant real-world differences in patients' carrying time, confidence in use, and training experiences between Auvi-Q and EpiPen users.
J Allergy Clin Immunol Pract
Adolescent; Adult; Age Factors; Aged; Anaphylaxis; Arthropod Venoms; Bronchodilator Agents; Child; Cross-Sectional Studies; Disease Management; Drug Hypersensitivity; Educational Status; Epinephrine; Family Characteristics; Female; Food Hypersensitivity; Humans; Income; Injections, Intramuscular; Insect Bites and Stings; Insurance, Health; Latex Hypersensitivity; Male; Middle Aged; Multivariate Analysis; Self Administration; Self Concept; Surveys and Questionnaires; Time Factors; Young Adult
Adrenaline; Allergic emergency; Anaphylaxis; Autoinjector; Auvi-Q; Carriage; EpiPen; Epinephrine; Questionnaire
Portnoy J, Wade RL, Kessler C. Patient Carrying Time, Confidence, and Training with Epinephrine Autoinjectors: The RACE Survey. J Allergy Clin Immunol Pract. 2019;7(7):2252-2261. doi:10.1016/j.jaip.2019.03.021