Title

Relationship Between Clinical Factors and Duration of IV Antibiotic Treatment in Neonatal UTI.

Document Type

Article

Publication Date

9-1-2020

Identifier

DOI: 10.1542/hpeds.2019-0325

Abstract

OBJECTIVES: To describe practice patterns of intravenous (IV) antibiotic treatment duration in term neonates ≤28 days old with a urinary tract infection (UTI).

METHODS: We performed a retrospective chart review of term neonates ≤28 days old hospitalized for UTI at 2 academic pediatric hospitals from 2012 to 2018. Neonates who were admitted to the PICU or with known preexisting renal and/or urologic anomalies or concomitant bacteremia were excluded. We examined clinical features, complications, and duration of IV antibiotic therapy. Univariate and multivariate analyses of long duration of IV antibiotics (>48 hours) were performed by using logistic regression.

RESULTS: Of 310 neonates identified by diagnostic codes and chart review, 112 met criteria for inclusion. The median IV antibiotic duration was 49 hours (51% received IV antibiotics for >48 hours), and the median total antibiotic duration was 10 days. No demographic features or laboratory values correlated with IV antibiotic duration apart from age(adjusted odds ratio [aOR] = 3.2;

CONCLUSIONS: Our study revealed the recent trend toward shorter IV antibiotic courses for healthy term neonates with UTI is inclusive of infants ≤28 days at these 2 sites. Few factors associated with neonates' initial clinical presentation appear to influence the length of IV antibiotic treatment.

Journal Title

Hosp Pediatr

Volume

10

Issue

9

First Page

743

Last Page

749

Library Record

Share

COinS