Obesity-related asthma in children: A role for vitamin D.
Excess adipose tissue predisposes to an enhanced inflammatory state and can contribute to the pathogenesis and severity of asthma. Vitamin D has anti-inflammatory properties and low-serum levels are seen in children with asthma and in children with obesity. Here we review the intersection of asthma, obesity, and hypovitaminosis D in children. Supplementation with vitamin D has been proposed as a simple, safe, and inexpensive adjunctive therapy in a number of disease states. However, little research has examined the pharmacokinetics of vitamin D and its therapeutic potential in children who suffer from obesity-related asthma.
asthma; children; inflammation; obesity; pediatric; vitamin D
O'Sullivan, B. P., James, L., Majure, J. M., Bickel, S., Phan, L., Serrano Gonzalez, M., Staples, H., Tam-Williams, J. B., Lang, J., Snowden, J., . Obesity-related asthma in children: A role for vitamin D. Pediatric pulmonology 56, 354-361 (2021).