Glucose Levels during the First 24 Hours following Perinatal Hypoxia.
OBJECTIVE: Hypoglycemia is a significant risk factor for perinatal brain injury and adverse outcomes, particularly in infants requiring resuscitation following hypoxic ischemic (HI) insult. We aimed to study blood glucose (BG) levels in physiologically stressed infants in the presence or absence of epinephrine (Epi) administration at resuscitation in the first 24 hours after birth.
STUDY DESIGN: A retrospective chart review of all infants with heart rate (HR) < 100/min at 1 minute requiring positive pressure ventilation (PPV) at birth was performed. Infants were classified into two groups as follows: (1)
RESULTS: By design, infants in the Epi group had lower cord pH and higher base deficit. BG was significantly lower overtime in premature infants ≤32 weeks of gestation in the Epi group. The BG was markedly higher in near-term and term infants in the Epi group compared with the PPV group. Hypoglycemia was more common despite administration of higher GIR in premature infants ≤32 weeks of gestation.
CONCLUSION: In the presence of physiological stress, premature infants are more at risk for hypoglycemia than term infants.
American journal of perinatology
Alsaleem, M., Zeinali, L. I., Mathew, B., Kumar, V. H. Glucose Levels during the First 24 Hours following Perinatal Hypoxia. American journal of perinatology 38, 490-496 (2021).