Title

The implementation of an aminoglycoside induced ototoxicity algorithm for people with cystic fibrosis.

Document Type

Article

Publication Date

3-2021

Identifier

DOI: 10.1016/j.jcf.2020.08.002

Abstract

Aminoglycoside antibiotics treat respiratory infections in cystic fibrosis (CF). An aminoglycoside induced ototoxicity algorithm (AIOA) was implemented to assess ototoxicity among people with CF treated with intravenous and/or inhaled aminoglycosides. Prior to AIOA implementation, 14 of 52 patients (27%) treated with intravenous aminoglycosides had an audiogram. In the 24 months post AIOA implementation, 43 of 44 patients (98%) treated with intravenous aminoglycosides had an audiogram, with 27 (63%) demonstrating abnormalities. Prior to AIOA development, 18 of 70 patients (26%) who received at least two courses of inhaled aminoglycosides had an audiogram. Post AIOA implementation, 33 patients qualified for an audiogram after receiving inhaled aminoglycosides. Of these, 19 (58%) had an audiogram and 10 (53%) had abnormalities. Overall, we identified 46 (61%) people with CF with hearing abnormalities compared to 2.4% in the CF Foundation Patient Registry. This suggests an urgent need for CF programs to implement AIOAs.

Journal Title

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Volume

20

Issue

2

First Page

284

Last Page

287

Keywords

Aminoglycoside; Cystic fibrosis; Ototoxicity

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