Gene expression in pediatric heart disease with emphasis on conotruncal defects.
DOI: 10.1016/j.ppedcard.2005.04.004; PMCID: PMC5436709
Developmental abnormalities of the heart are the underlying cause of many congenital heart malformations. The embryological development of the integrated cardiovascular tissue is the result of multiple tissue and cell-to-cell interactions involving temporal and spatial events under genetic control. Recent technological advances, like microarray analysis of gene expression, are providing new tools to aid in deciphering the complex networks of gene expression that regulate cardiac development. Here, we review our current understanding of the genetics of congenital heart disorders with emphasis on gene expression studies and report preliminary data from infants with conotruncal defects. We report our microarray analysis showing over- and underexpression of individual genes and gene network interactions from dysplastic pulmonic tissue from two infants with tetralogy of Fallot compared with normal pulmonic tissue from an unaffected control infant.
Progress in pediatric cardiology
Cardiac development; Congenital heart defects; Conotruncal defects; Gene expression; Microarray; Pediatric cardiology
Bittel, D. C., Kibiryeva, N., O'Brien, J. E., Lofland, G. K., Butler, M. G. Gene expression in pediatric heart disease with emphasis on conotruncal defects. Progress in pediatric cardiology 20, 127-141 (2005).