DOI: 10.1111/cts.12952; PMCID: PMC8212707
Nonalcoholic fatty liver disease (NAFLD) affects up to 70% of children with obesity and has become the number one etiology for liver transplant in the United States. Early, effective intervention is critical to prevent disease progression into adulthood. Yet, it is seldom achieved through lifestyle modification alone. Thus, children must be included in NAFLD pharmacology trials, which, to date, continue to focus primarily on adult populations. This commentary serves as a call to action.
Clin Transl Sci
Friesen, C. S., Chan, S. S., Wagner, J. B., Hosey-Cojocari, C., Csanaky, I., Shakhnovich, V. Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective. Clin Transl Sci 14, 781-783 (2021).