PharmVar GeneFocus: CYP3A5.

Document Type

Article

Publication Date

12-2022

Identifier

DOI: 10.1002/cpt.2563

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the immunosuppressants tacrolimus, sirolimus, cyclosporine, and the benzodiazepine midazolam. Variable CYP3A5 activity is of clinical importance regarding tacrolimus metabolism. This GeneFocus provides a CYP3A5 gene summary with a focus on aspects regarding standardized nomenclature. In addition, this review also summarizes recent changes and updates, including the retirement of several allelic variants and provides an overview of how PharmVar CYP3A5 star allele nomenclature is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Journal Title

Clinical pharmacology and therapeutics

Volume

112

Issue

6

First Page

1159

Last Page

1171

MeSH Keywords

Humans; Cytochrome P-450 CYP3A; Tacrolimus; Immunosuppressive Agents; Pharmacogenetics; Cyclosporine; Genotype

Keywords

Cytochrome P-450 CYP3A; Tacrolimus; Immunosuppressive Agents; Pharmacogenetics; Cyclosporine; Genotype

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