Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

Document Type

Article

Publication Date

3-2018

Identifier

DOI: 10.1002/cpt.890; PMCID: PMC5805563

Abstract

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.

Journal Title

Clinical pharmacology and therapeutics

Volume

103

Issue

3

First Page

390

Last Page

394

MeSH Keywords

Genetic Predisposition to Disease; Genetic Testing; Humans; Incidence; Necrosis; Predictive Value of Tests; Stevens-Johnson Syndrome

PubMed ID

29105735

Keywords

Genetic Predisposition to Disease; Genetic Testing; Humans; Incidence; Necrosis; Predictive Value of Tests; Stevens-Johnson Syndrome

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