Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.

Creator(s)

Li Q. Zhang
Marianne Nsumu
Peixin Huang
Daniel P. Heruth, Children's Mercy HospitalFollow
Sean M. Riordan
Katherine Shortt
Nini Zhang
Dmitry N. Grigoryev
Ding-You Li, Children's Mercy HospitalFollow
Craig A. Friesen, Children's Mercy HospitalFollow
Leon Van Haandel, Children's Mercy Kansas City
J Steven Leeder, Children's Mercy HospitalFollow
Jody Olson
Shui Q. Ye

Document Type

Article

Publication Date

7-1-2018

Identifier

DOI: 10.1016/j.ajpath.2018.04.004; PMCID: PMC6024191

Abstract

Acetaminophen overdose is the most common cause of acute liver injury (ALI) or acute liver failure in the United States. Its pathogenetic mechanisms are incompletely understood. Additional studies are warranted to identify new genetic risk factors for more mechanistic insights and new therapeutic target discoveries. The objective of this study was to explore the role and mechanisms of nicotinamide phosphoribosyltransferase (NAMPT) in acetaminophen-induced ALI. C57BL/6 Nampt gene wild-type (Nampt

Journal Title

The American journal of pathology

Volume

188

Issue

7

First Page

1640

Last Page

1652

MeSH Keywords

Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Protective Agents

PubMed ID

29684358

Keywords

Acetaminophen; Non-Narcotic Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Protective Agents

Comments

Grants and funding

• R01 HL080042/HL/NHLBI NIH HHS/United States

Recommended Citation

Zhang LQ, Nsumu M, Huang P, et al. Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice. Am J Pathol. 2018;188(7):1640-1652. doi:10.1016/j.ajpath.2018.04.004