Drug Administration and Pharmacogenomics in Children Receiving Acute or Chronic Renal Replacement Therapy

Creator(s)

Bridget L. Blowey
J Steven Leeder, Children's Mercy HospitalFollow
Douglas Blowey, Children's Mercy Kansas CityFollow

Document Type

Book Chapter

Publication Date

3-2021

Identifier

DOI: 10.1007/978-3-030-66861-7_36

Abstract

The prescription of a safe and effective dose of a medication for a child receiving dialysis can be a complicated task as both renal failure and dialysis can modify the absorption, distribution, metabolism, elimination, and action of a drug. A safe and effective dosing regimen is one that delivers the appropriate drug in the optimal manner, producing the desired pharmacological response while minimizing the undesirable effects. Achieving the goal of successful drug therapy requires a clear understanding of the therapeutic goal coupled with an appreciation of the factors governing drug disposition and action. Failure to clearly identify the therapeutic goal or to account for the changes in drug disposition or effectiveness associated with renal failure and the performance of dialysis can culminate in drug toxicity or inadequate treatment.

Journal Title

Pediatric Dialysis

First Page

683

Last Page

707

Recommended Citation

Blowey, B.L., Leeder, J.S., Blowey, D.L. (2021). Drug Administration and Pharmacogenomics in Children Receiving Acute or Chronic Renal Replacement Therapy. In: Warady, B.A., Alexander, S.R., Schaefer, F. (eds) Pediatric Dialysis. Springer, Cham. https://doi.org/10.1007/978-3-030-66861-7_36