Cardiometabolic Risk Factors, Metabolic Syndrome, and Chronic Kidney Disease Progression in Children.

Document Type

Article

Publication Date

11-2018

Identifier

DOI: 10.1016/j.jpeds.2018.06.007; PMCID: PMC6203642

Abstract

OBJECTIVE: To estimate the prevalence of metabolic syndrome (MetS) and examine its association with chronic kidney disease progression in children enrolled in the Chronic Kidney Disease in Children study.

STUDY DESIGN: MetS was defined as being overweight or obese and having ≥2 cardiometabolic risk factors (CMRFs). Incidence and prevalence of MetS were assessed using pairs of visits approximately 2 years apart.

RESULTS: A total of 799 pairs of person-visits (contributed by 472 children) were included in the final analysis. Of these, 70% had a normal body mass index (BMI), 14% were overweight, and 16% were obese. At the first visit, the prevalence of MetS in the overweight group was 40% and in the obese group was 60%. In adjusted models, annual percent estimated glomerular filtration rate decline in those who had normal BMI and incident or persistent multiple CMRFs or those with persistent MetS was -6.33%, -6.46%, and -6.08% (respectively) compared with children who never had multiple CMRFs (-3.38%, P = .048, .045, and .036, respectively). Children with normal BMI and incident multiple CMRFs and those with persistent MetS had approximately twice the odds of fast estimated glomerular filtration rate decline (>10% per year) compared with those without multiple CMRFs and normal BMI.

CONCLUSION: Children with chronic kidney disease have a high prevalence of MetS. These children as well as those with normal BMI but multiple CMRFs experience a faster decline in kidney function.

Journal Title

The Journal of pediatrics

Volume

202

First Page

163

Last Page

170

MeSH Keywords

Age Factors; Body Mass Index; Cardiovascular Diseases; Child; Cohort Studies; Comorbidity; Disease Progression; Female; Glomerular Filtration Rate; Humans; Male; Metabolic Syndrome; Obesity; Prevalence; Prognosis; Renal Insufficiency, Chronic; Risk Assessment; Sex Factors; Statistics, Nonparametric; United States

PubMed ID

30041938

Keywords

cardiovascular risk; children; chronic kidney disease; metabolic syndrome

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