Management of Anemia in Children Receiving Chronic Dialysis

Creator(s)

Meredith A. Atkinson
Bradley A. Warady, Children's Mercy HospitalFollow

Document Type

Book Chapter

Publication Date

3-2021

Identifier

DOI: 10.1007/978-3-030-66861-7_32

Abstract

In 1839, the Scottish physician Robert Christison noted that anemia was a common feature of kidney disease, writing that “no other natural disease came as close to hemorrhage for impoverishing the red particles of the blood” [1, 2]. Anemia is a comorbidity affecting nearly all children treated with chronic dialysis, and its management remains challenging for clinicians. The emergence of recombinant human erythropoietin (rHuEPO) more than 30 years ago revolutionized anemia management in the dialysis population and eliminated dependence on red blood cell transfusions for most patients. Increased understanding of the molecular regulation of EPO production and iron metabolism has opened the door for the development of novel erythropoiesis-stimulating agents (ESA) and renal anemia therapies.

Journal Title

Pediatric Dialysis

First Page

609

Last Page

631

Recommended Citation

Atkinson, M.A., Warady, B.A. (2021). Management of Anemia in Children Receiving Chronic Dialysis. In: Warady, B.A., Alexander, S.R., Schaefer, F. (eds) Pediatric Dialysis. Springer, Cham. https://doi.org/10.1007/978-3-030-66861-7_32