Pediatric therapeutic drug monitoring, toxicology and pharmacogenomics

Creator(s)

Uttam Garg, Children's Mercy HospitalFollow
Tracy L. Sandritter, Children's Mercy HospitalFollow
Andrea Gaedigk, Children's Mercy Kansas CityFollow

Document Type

Book Chapter

Publication Date

2021

Identifier

DOI: 10.1016/B978-0-12-817962-8.00021-4

Abstract

Various physiological differences lead to significant differences in therapeutic drug monitoring(TDM) and toxicology between children and adults. These factors include differences in gastric pH, intestinal transit time, membrane permeability, liver maturity, first-pass metabolism, renal clearance, protein binding, protein concentration, and enzyme activities. These differences lead to significant variations in pharmacodynamics and pharmacokinetics among children and adults. Understanding of these differences further requires understanding of pharmacogenetic and pharmacogenomic principles.

Journal Title

Biochemical and Molecular Basis of Pediatric Disease (Fifth Edition)

First Page

849

Last Page

908

Recommended Citation

Garg U, Sandritter TL, Gaedigk A. Pediatric therapeutic drug monitoring, toxicology and Pharmacogenomics. Biochemical and Molecular Basis of Pediatric Disease. Published online 2021:849-908. doi:10.1016/b978-0-12-817962-8.00021-4