Document Type
Article
Publication Date
4-14-2025
Identifier
DOI: 10.3390/jcdd12040156; PMCID: PMC12027825
Abstract
Congenital long QT syndrome (LQTS) is a group of heritable conditions that are associated with cardiac repolarization abnormalities characterized by QT prolongation on electrocardiogram and the risk of life-threatening arrhythmias. The prenatal detection of LQTS presents significant challenges for clinicians, and a multidisciplinary approach is required for optimal prenatal and postnatal management. In this comprehensive literature review, we describe strategies for the fetal diagnosis of LQTS with variable initial presentation, genetic testing in suspected fetal LQTS, the utility of fetal magnetocardiography as an additional diagnostic tool, prenatal management, and postnatal treatment. We focus on a multidisciplinary team approach including fetal cardiology, adult and pediatric electrophysiology, neonatology, maternal-fetal medicine, and genetic counselors, all playing vital roles in the comprehensive prenatal management and orchestration of postnatal treatment to optimize neonatal outcomes.
Journal Title
J Cardiovasc Dev Dis
Volume
12
Issue
4
First Page
156
PubMed ID
40278215
Keywords
arrhythmia; electrophysiology; fetal echocardiography; fetal magnetocardiography; genetics; inherited arrhythmia syndrome
Recommended Citation
Samples S, Cherny S, Madan N, et al. The Prenatal Diagnosis and Perinatal Management of Congenital Long QT Syndrome: A Comprehensive Literature Review and Recent Updates. J Cardiovasc Dev Dis. 2025;12(4):156. Published 2025 Apr 14. doi:10.3390/jcdd12040156
Comments
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Publisher's Link: https://www.mdpi.com/2308-3425/12/4/156