Left ventricular dysfunction is associated with intraventricular dyssynchrony by 3-dimensional echocardiography in children.
INTRODUCTION: We used 3-dimensional (3D) echocardiography to identify and quantify left ventricular (LV) dyssynchrony in children with LV dysfunction compared with control subjects.
METHODS: The 3D echocardiography LV full volumes were acquired in 18 children, 9 with LV dysfunction and 9 control subjects. The LV was subdivided into 16 segments (apex excluded). Time from end diastole to the minimal systolic volume for each segment was expressed as a percent of the R-R interval. The SD of these times provided a 16-segment dyssynchrony index (16-SDI). The second index (12-SDI) was similarly calculated using 6 basal and 6 mid segments. The third index consisted of 6 basal segments (6-SDI).
RESULTS: The dysfunction group exhibited significantly increased 16-SDI (P = .008) and 12-SDI (P = .01). The 16-SDI was negatively correlated with 3D ejection fraction and 2-dimensional fractional shortening.
CONCLUSIONS: Children with LV dysfunction demonstrate increased intraventricular LV dyssynchrony by 3D echocardiography, in a pattern that is negatively correlated with LV systolic function.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Child; Child, Preschool; Echocardiography, Three-Dimensional; Humans; Image Interpretation, Computer-Assisted; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Ventricular Dysfunction, Left; Ventricular Fibrillation
Baker, G. H., Hlavacek, A. M., Chessa, K. S., Fleming, D. M., Shirali, G. S. Left ventricular dysfunction is associated with intraventricular dyssynchrony by 3-dimensional echocardiography in children. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 21, 230-233 (2008).