Publication Date

5-2025

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Abstract

Introduction: Osteopetrosis is comprised of a group of rare hereditary disorders characterized by impaired osteoclast development or activity resulting in altered bone metabolism and high bone mineral density. Resulting bone is denser and heavier but more fragile than healthy bone. This condition can have oral manifestations such as malformed teeth, hypomineralization, or agenesis of teeth. The treatment for osteopetrosis can include hematopoietic stem cell transplantation and recommendations for prophylactic dental treatment7. The purpose of this report is to present a review of the literature regarding the dental considerations for patients with osteopetrosis. Case Report: This case report details a six-year-old male who initially presented to the Children’s Mercy Dental Clinic in 2020 for dental clearance prior to a bone marrow transplant and the subsequent follow up care over the next four years. The patient’s medical history is significant for osteopetrosis status post bone marrow transplant in 2020 as well as numerous medical diagnoses. Clinical and radiographic examination revealed carious primary teeth and multiple malformed, hypoplastic, or unerupted successor teeth. Clinical considerations for this patient include managing carious teeth as well as providing the parent with recommendations regarding future care are presented in this report.

Disciplines

Pediatric Dentistry and Pedodontics

Notes

Presented at the American Academy of Pediatric Dentistry Annual Session; Denver, Colorado; May 22-25, 2025.

Dental Considerations for a Pediatric Patient with Osteopetrosis: Case Report

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