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Home > PODCASTS > TRANSFORMATIONAL-PEDS_PODCAST

Transformational Pediatrics Podcast

Transformational Pediatrics Podcast

 

Transformational Pediatrics features interviews with physicians and researchers at Children’s Mercy Kansas City who are transforming pediatric care through genomic medicine, personalized therapeutics, health services and outcomes research, and innovations in health care delivery.

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  • Health Care Informatics by Andrew Wilner and Jill Westcott

    Health Care Informatics

    Andrew Wilner and Jill Westcott

    What is informatics and why is it important in health care? Listen as Jill Westcott, MD, MS, FACOG, Physician Informaticist for the Fetal Health Center at Children's Mercy, shares her expertise on the topic and how informatics is improving patient outcomes in fetal health.

    Click here to stream the podcast episode.

  • Genomic Answers for Kids Establishes New Paradigm in Rare Disease Research by Melanie Cole and Tomi Pastinen

    Genomic Answers for Kids Establishes New Paradigm in Rare Disease Research

    Melanie Cole and Tomi Pastinen

    The Children’s Mercy Research Institute® is undertaking a research initiative to build a first-of-its-kind pediatric data repository to facilitate the search for answers and novel treatments for pediatric genetic conditions. Our goal is to collect genomic data and health information for 30,000 children and their families over the next seven years, creating a database of nearly 100,000 genomes.

    Click here to stream the podcast episode.

  • Transforming Pediatric Research by Melanie Cole and Tom Curran

    Transforming Pediatric Research

    Melanie Cole and Tom Curran

    How do we create a healthier future for children? The Children's Mercy Research Institute with a core focus on genomics, personalized therapeutics, population health, health care innovation and bioethics is positioned to fundamentally transform pediatric research and create a world of well-being for all children. Listen as Thomas Curran, PhD, FRS, Chief Scientific Officer, discusses the institute and the future of pediatric research.

    Click here to stream the podcast episode.

  • Achieving Transplant Excellence Through Personalized Medicine by Melanie Cole and Bradley Warady

    Achieving Transplant Excellence Through Personalized Medicine

    Melanie Cole and Bradley Warady

    Children’s Mercy Kansas City is recognized as one of the top 10 nephrology programs in the nation by U.S. News & World Report, and the kidney transplant program has incorporated a number of innovative practices into their management plan that are designed to enhance patient outcomes. Join us as Dr. Bradley Warady discusses how the program’s personalized approach to meeting each patient’s unique needs — including repeated surveillance biopsies, epitope matching and pharmacokinetic assessment of immunosuppressive medication — has contributed to a 100% three-year patient and graft survival rate for the past six years.

    Click here to stream the podcast episode.

  • Pediatric Hemodialysis and Advances in Infection Prevention and Vascular Preservation by Melanie Cole and Bradley A. Warady

    Pediatric Hemodialysis and Advances in Infection Prevention and Vascular Preservation

    Melanie Cole and Bradley A. Warady

    To reduce the risk of complications related to hemodialysis, the Children’s Mercy Kansas City Division of Nephrology has implemented several strategies. Listen as Dr. Bradley Warady shares how the institution of standardized infection prevention practices has resulted in more than 1,200 consecutive days without an outpatient central line-associated blood stream infection (CLABSI) in a hemodialysis (HD) patient. In addition, Dr. Warady discusses how vascular preservation protocols also are improving the long-term venous access options for these and future patients.

    Click here to stream the podcast episode.

  • Impact of Race & Ethnicity on Responses to Folic Acid Dosing by Melanie Cole and Devika Maulik

    Impact of Race & Ethnicity on Responses to Folic Acid Dosing

    Melanie Cole and Devika Maulik

    Devika Maulik MD shares her translational research as it relates to folic acid and different responses to dosing among women of various races and ethnicities. She is using the information gathered to create recommended guidelines for folic acid dosing. She discusses current literature on this topic, as well as her studies in this area.

    Click here to stream the podcast episode.

  • Pediatric Recurrent Intentional Foreign Body Ingestion: Case Series and Review of the Literature by Melanie Cole and Christina M. Low Kapalu

    Pediatric Recurrent Intentional Foreign Body Ingestion: Case Series and Review of the Literature

    Melanie Cole and Christina M. Low Kapalu

    Dr. Christina Low Kapalu discusses cases and literature surrounding pediatric recurrent intentional foreign body ingestion.

    Click here to stream the podcast episode.

  • Variations in Morning Serum Cortisol Levels Based on Sex and Pubertal Status by Melanie Cole and Sarah Tsai

    Variations in Morning Serum Cortisol Levels Based on Sex and Pubertal Status

    Melanie Cole and Sarah Tsai

    Dr. Sarah Tsai discusses his recent findings from his study surround serum morning cortisol levels.

    Click here to stream the podcast episode.

  • Twin to Twin Transfusion Syndrome: Algorithm for Diagnosing and Treating by Melanie Cole and Emanuel Vlastos

    Twin to Twin Transfusion Syndrome: Algorithm for Diagnosing and Treating

    Melanie Cole and Emanuel Vlastos

    Dr. Emanuel "Mike" Vlastos discusses the algorithm for diagnosing and trading twin to twin transfusion syndrome.

    Click here to stream the podcast episode.

  • Improved Outcomes for Liver Transplantation with Biliary Atresia by Melanie Cole and James F. Daniel

    Improved Outcomes for Liver Transplantation with Biliary Atresia

    Melanie Cole and James F. Daniel

    Dr. James Daniel discusses improved outcomes for liver transplantation with Biliary Atresia.

    Click here to stream the podcast episode.

  • Clinical Characteristics of Fractures in Pediatric Patients Exposed to PPIs by Michael Smith and Nathan R. Fleishman

    Clinical Characteristics of Fractures in Pediatric Patients Exposed to PPIs

    Michael Smith and Nathan R. Fleishman

    Dr. Nathan Fleishman discusses the clinical characteristics of fractures in pediatric patients exposed to PPIs.

    Click here to stream the podcast episode.

  • Pediatric Provider Well-Being and the COVID-19 Pandemic by Melanie Cole and Jennifer Bickel

    Pediatric Provider Well-Being and the COVID-19 Pandemic

    Melanie Cole and Jennifer Bickel

    The COVID-19 pandemic has created an unprecedented work environment for pediatricians and pediatric subspecialists. How we practice medicine has been dramatically changed. When discussing physical precautions such as PPE and social distancing, provider mental well-being also should be a part of the conversation.

    In this podcast, Jennifer Bickel, MD, pediatric neurologist and Medical Director of the Children’s Mercy Center for Professional Well-Being, discusses how pediatricians have responded to the pandemic on a personal and professional level, the impact on physical and mental health, adjusting to the decrease in patient and peer contact, warning signs of burnout and mental health issues, steps Children’s Mercy is taking to address physician well-being, and more.

    Click here to stream the podcast episode.

  • Preventing Type 2 Diabetes by Michael Smith and Kelsee Halpin

    Preventing Type 2 Diabetes

    Michael Smith and Kelsee Halpin

    Dr. Kelsee Halpin discusses Endocrinology and Diabetes.

    Click here to stream the podcast episode.

  • Bariatric Surgery by Michael Smith and Jason D. Fraser

    Bariatric Surgery

    Michael Smith and Jason D. Fraser

    Childhood Obesity continues to be on the rise and causes serious health consequences. In this podcast, Dr. Jason Fraser discusses the Bariatric Surgery program at Children's Mercy. We learn who is a candidate for bariatric surgery, the requirements for surgery, why Children's Mercy decided to offer bariatric surgery, the type of bariatric surgery offered at Children's Mercy and results.

    Click here to stream the podcast episode.

  • Polycystic Ovary Syndrome: Current Concepts for A Complex Condition by Michael Smith and Tania S. Burgert

    Polycystic Ovary Syndrome: Current Concepts for A Complex Condition

    Michael Smith and Tania S. Burgert

    Dr. Tania Burgert discusses Polycystic Ovary Syndrome (PCOS) and the current ideas surrounding a complex condition.

    Click here to stream the podcast episode.

  • How the Cardiac High Acuity Monitoring Program (CHAMP) is Helping Change Lives by Michael Smith and Hayley S. Hancock

    How the Cardiac High Acuity Monitoring Program (CHAMP) is Helping Change Lives

    Michael Smith and Hayley S. Hancock

    CHAMP (Cardiac High Acuity Monitoring Program) is a multi-disciplinary based team that has been designed to meet the needs of the most complex cardiac population with single ventricle heart disease. The program closely monitors patients with single ventricle heart disease between the critical first and second stages (before stage II Glenn surgery). The team at the Ward Family Heart Center at Children's Mercy has also developed a tool that makes it easier for families to report their single ventricle child's vital signs from home and provides the hospital team with frequent updates needed to keep these patients well between visits. Dr. Hancock discusses everything you need to know about CHAMP.

    Click here to stream the podcast episode.

  • CKiD Expansion by Michael Smith and Bradley A. Warady

    CKiD Expansion

    Michael Smith and Bradley A. Warady

    The CKiD study was recently approved for an additional five years and $4.7 million of funding, making 20 consecutive years of funding. Historically, when participants developed end-stage disease, they left the study. The next phase of study will focus on the entire spectrum of the disease, starting with early CKiD in infants and following those who progress to kidney failure, requiring dialysis and transplant. Currently, CKiD is enrolling an additional 190 children in the new cohort. The study will attempt to detect abnormalities earlier in the process for more timely interventions.

    Click here to stream the podcast episode.

  • Targeted Therapy to Reduce Relapse of Pediatric Leukemia by Michael Smith and John M. Perry

    Targeted Therapy to Reduce Relapse of Pediatric Leukemia

    Michael Smith and John M. Perry

    Patients that have residual leukemia stem cells after chemotherapy and other treatments have substantially higher risk for relapse. Survival rates for relapsed leukemia are very poor. Even when patients survive long-term, the very toxic anti-cancer treatments are escalated in treating relapsed leukemia. This particularly risks long-term health and substantially increases the risk of early death due to side-effects of the treatment itself.

    John Perry, PhD, faculty member of the Children's Research Institute at Children's Mercy Kansas City is studying how leukemia stem cells resist current anti-cancer treatments.

    Join us for this podcast as Dr. Perry discusses the promise of low-dose doxorubicin as a targeted therapy against leukemia stem cells rather than a broadly toxic chemotherapy drug.

    Click here to stream the podcast episode.

  • Identifying Novel Drug Treatment Options for Pediatric Osteosarcoma by Michael Smith and Tomoo Iwakuma

    Identifying Novel Drug Treatment Options for Pediatric Osteosarcoma

    Michael Smith and Tomoo Iwakuma

    Osteosarcoma is highly metastatic and drug-resistant cancer. The survival rate for metastatic osteosarcoma remains less than 20 percent for the last 40 years. Tomoo Iwakuma, MD, PhD, is leading research focused on the elucidation of mechanisms underlying osteosarcoma progression and the discovery of novel drugs against this osteosarcoma. His laboratory has identified a lead compound that specifically killed canine and human osteosarcoma cells lacking the activity of the tumor suppressor p53, with minimal impact on non-tumor cells. Join us as we visit with Dr. Iwakuma about this promising research.

    Click here to stream the podcast episode.

  • Management and Treatment for Peutz-Jeghers Syndrome by Michael Smith, Thomas M. Attard, and Caitlin E. Lawson

    Management and Treatment for Peutz-Jeghers Syndrome

    Michael Smith, Thomas M. Attard, and Caitlin E. Lawson

    Peutz-jeghers syndrome (PJS) is an inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. Individuals that present with PJS tend to have polyps often in their small intestine as well as their stomach and large intestine. Recently the European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) group published the first set of guidelines in treating PJS in pediatric patients.

    Hear from Thomas Attard MD, a core contributing author to the ESPGHAN guidelines and Caitlin Lawson, MS, CGC, on how Children’s Mercy manages pediatric patients in view of the new recommendations and how novel techniques available at Children’s Mercy impact patient management and outcomes.

    Click here to stream the podcast episode.

  • Getting in Front of Type 2 Diabetes by Michael Smith and Yun Yan

    Getting in Front of Type 2 Diabetes

    Michael Smith and Yun Yan

    Type 2 diabetes was commonly associated with the adult population. This diagnosis was even referenced as adult-onset diabetes but in recent years type 2 diabetes in children is on the rise.

    Although researchers aren’t clear as to why some children develop type 2 diabetes there are some causes that can increase the risk. When children present with these risks the Children Mercy Diabetes Center can evaluate these patients and create a care plan to possibly alter the path to such a diagnosis.

    Hear from Dr. Yan as she explains the types of children that can be seen in clinic and how to proactively get in front of a life altering diagnosis of type 2 diabetes.

    Click here to stream the podcast episode.

  • Is There a Role for Fecal Transplant in IBD? by Michael Smith and Alka Goyal

    Is There a Role for Fecal Transplant in IBD?

    Michael Smith and Alka Goyal

    Can an effective treatment for medically refractive Crohn’s disease be found in the gastrointestinal tract itself?

    Dr. Alka Goyal with Children’s Mercy Kansas City is exploring the role of fecal transplant as a rescue therapy for patients whose inflammatory bowel disease has not responded to traditional treatment. Early research showed that a single transplant is relatively safe and can result in a short-term response in young patients with active IBD but doesn’t provide long-term relief. Now Dr. Goyal is launching a new study to help determine whether there is an advantage to a stronger induction phase for transplant, and any benefit to performing maintenance therapy for patients with Crohn’s.

    Dr. Goyal highlights her research findings recently published in the IBD Journal, reviews her next study and the potential it holds for patients whose disease requires longer-term effective therapy.

    Click here to stream the podcast episode.

  • Tourette Syndrome: Using an Evidence-based Algorithm to Guide Treatment by Michael Smith, Keith A. Coffman, and Julio Quezada

    Tourette Syndrome: Using an Evidence-based Algorithm to Guide Treatment

    Michael Smith, Keith A. Coffman, and Julio Quezada

    As an expert in the treatment of Tourette Syndrome (TS), recently, Dr. Coffman was asked to author an article on the pharmacological treatment of Tourette Syndrome.

    In collaboration with Dr. Quezada, the paper was published in CNS Drugs Journal, focusing on current approaches and new developments regarding treatment of Tourette Syndrome. The team developed a visual algorithm to help guide the treatment of TS using medication based on the level-of-evidence and side-effects. It has been designed for others to use both inside the U.S. and globally. In this podcast, Drs. Coffman and Quezada will discuss the findings of the review publication.

    Click here to stream the podcast episode.

  • Precision Therapeutics in the NICU by Michael Smith and Tamorah R. Lewis

    Precision Therapeutics in the NICU

    Michael Smith and Tamorah R. Lewis

    Neonatal pharmacotherapy is a field ripe with opportunity. Efficacy and toxicity is unpredictable and varies greatly for many drug classes commonly used. Weight-based dosing continues to be the standard of care as individualized drug markers are lacking. To better understand variability in drug response, the focus must shift from drug dosing to drug exposure.

    Tamorah Lewis, MD, neonatologist and clinical pharmacologist, joins us to discuss how pharmacotherapy and individualized medicine can transform care for critically ill newborns.

    Click here to stream the podcast episode.

  • Cancer Genomics: Finding Answers Through Data and DNA by Michael Smith and Erin M. Guest

    Cancer Genomics: Finding Answers Through Data and DNA

    Michael Smith and Erin M. Guest

    Approximately 10 to 15 percent of childhood cancer cases are due to a genetic predisposition. Children’s Mercy Kansas City is searching within the genetic code to not only identify genes that may lead to cancer, but to find answers in how to better treat or cure pediatric cancer.

    Erin Guest, MD, Director of Cancer Genomics at Children’s Mercy, discusses the growing role of cancer genomics and how big data, new tests, and personalized treatments could change the future of pediatric cancer treatment.

    Click here to stream the podcast episode.

 
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Children's Mercy, located in Kansas City, Mo., is one of the nation's top pediatric medical centers. The not-for-profit hospital provides care for children from birth through the age of 21, and is ranked by U.S. News & World Report as one of "America's Best Children's Hospitals.“ Visit childrensmercy.org

 
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