Document Type

Critically Appraised Topic

Publication Date

4-2026

Specific Care Question

In pediatric patients with underlying liver disease and acute cholangitis without bacteremia, how does the use of a narrow-spectrum antimicrobial regimen (e.g., ceftriaxone + metronidazole) compare with a broad-spectrum regimen (e.g., piperacillin-tazobactam) in terms of clinical resolution, recurrence rates, or prevention of complications (e.g., biliary sepsis, abscess, increased length of stay)?

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