Factors associated with neurodevelopment for children with single ventricle lesions.

Creator(s)

Caren S. Goldberg
Minmin Lu
Lynn A. Sleeper
William T. Mahle
J William Gaynor
Ismee A. Williams
Kathleen A. Mussatto
Richard G. Ohye
Eric M. Graham
Deborah U. Frank
Jeffrey P. Jacobs
Catherine Krawczeski
Linda Lambert
Alan Lewis
Victoria L. Pemberton
Renee Sananes
Erica Sood
Stephanie B. Wechsler
David C. Bellinger
Jane W. Newburger
Pediatric Heart Network Investigators
Girish S. Shirali, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

9-1-2014

Identifier

PMCID: PMC4356168 DOI: 10.1016/j.jpeds.2014.05.019

Abstract

OBJECTIVE: To measure neurodevelopment at 3 years of age in children with single right-ventricle anomalies and to assess its relationship to Norwood shunt type, neurodevelopment at 14 months of age, and patient and medical factors.

STUDY DESIGN: All subjects in the Single Ventricle Reconstruction Trial who were alive without cardiac transplant were eligible for inclusion. The Ages and Stages Questionnaire (ASQ, n = 203) and other measures of behavior and quality of life were completed at age 3 years. Medical history, including measures of growth, feeding, and complications, was assessed through annual review of the records and phone interviews. The Bayley Scales of Infant Development, Second Edition (BSID-II) scores from age 14 months were also evaluated as predictors.

RESULTS: Scores on each ASQ domain were significantly lower than normal (P < .001). ASQ domain scores at 3 years of age varied nonlinearly with 14-month BSID-II. More complications, abnormal growth, and evidence of feeding, vision, or hearing problems were independently associated with lower ASQ scores, although models explained

CONCLUSION: Children with single right-ventricle anomalies have impaired neurodevelopment at 3 years of age. Lower ASQ scores are associated with medical morbidity, and lower BSID-II scores but not with shunt type. Because only a modest percentage of variation in 3-year neurodevelopmental outcome could be predicted from early measures, however, all children with single right-ventricle anomalies should be followed longitudinally to improve recognition of delays.

Journal Title

The Journal of pediatrics

Volume

165

Issue

3

First Page

490

Last Page

496

MeSH Keywords

Child, Preschool; Developmental Disabilities; Female; Heart Defects, Congenital; Heart Ventricles; Humans; Infant; Male; Nervous System; Prospective Studies

Keywords

Brain Development; Congenital heart defects; CHD

Recommended Citation

Goldberg, C. S., Lu, M., Sleeper, L. A., Mahle, W. T., Gaynor, J. W., Williams, I. A., Mussatto, K. A., Ohye, R. G., Graham, E. M., Frank, D. U., Jacobs, J. P., Krawczeski, C., Lambert, L., Lewis, A., Pemberton, V. L., Sananes, R., Sood, E., Wechsler, S. B., Bellinger, D. C., Newburger, J. W., ., Shirali, G. S. Factors associated with neurodevelopment for children with single ventricle lesions. The Journal of pediatrics 165, 490-496 (2014).