Document Type

Article

Publication Date

11-2023

Identifier

DOI: 10.1017/ice.2023.56; PMCID: PMC10665883

Abstract

OBJECTIVE: To describe patterns of inappropriate antibiotic prescribing at US children's hospitals and how these patterns vary by clinical service.

DESIGN: Serial, cross-sectional study using quarterly surveys.

SETTING: Surveys were completed in quarter 1 2019-quarter 3 2020 across 28 children's hospitals in the United States.

PARTICIPANTS: Patients at children's hospitals with ≥1 antibiotic order at 8:00 a.m. on institution-selected quarterly survey days.

METHODS: Antimicrobial stewardship physicians and pharmacists collected data on antibiotic orders and evaluated appropriateness of prescribing. The primary outcome was percentage of inappropriate antibiotics, stratified by clinical service and antibiotic class. Secondary outcomes included reasons for inappropriate use and association of infectious diseases (ID) consultation with appropriateness.

RESULTS: Of 13,344 orders, 1,847 (13.8%) were inappropriate; 17.5% of patients receiving antibiotics had ≥1 inappropriate order. Pediatric intensive care units (PICU) and hospitalists contributed the most inappropriate orders (n = 384 and n = 314, respectively). Surgical subspecialists had the highest percentage of inappropriate orders (22.5%), and 56.8% of these were for prolonged or unnecessary surgical prophylaxis. ID consultation in the previous 7 days was associated with fewer inappropriate orders (15% vs 10%; P < .001); this association was most pronounced for hospitalist, PICU, and surgical and medical subspecialty services.

CONCLUSIONS: Inappropriate antibiotic use for hospitalized children persists and varies by clinical service. Across 28 children's hospitals, PICUs and hospitalists contributed the most inappropriate antibiotic orders, and surgical subspecialists' orders were most often judged inappropriate. Understanding service-specific prescribing patterns will enable antimicrobial stewardship programs to better design interventions to optimize antibiotic use.

Journal Title

Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America

Volume

44

Issue

11

First Page

1711

Last Page

1717

MeSH Keywords

Humans; Child; United States; Anti-Bacterial Agents; Cross-Sectional Studies; Antimicrobial Stewardship; Surveys and Questionnaires; Practice Patterns, Physicians'; Hospitals; Inappropriate Prescribing

Keywords

United States; Anti-Bacterial Agents; Cross-Sectional Studies; Antimicrobial Stewardship; Surveys and Questionnaires; Physicians' Practice Patterns; Hospitals; Inappropriate Prescribing

Comments

This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher's Link: https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/appropriateness-of-antibiotic-prescribing-varies-by-clinical-services-at-united-states-childrens-hospitals/3EEB87302913E0362AD3EEEC6B2588BC

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