Document Type

Article

Publication Date

5-2024

Identifier

DOI: 10.1002/cyto.b.22175

Abstract

The assessment of T-cell clonality by flow cytometry has long been suboptimal, relying on aberrant marker expression and/or intensity. The introduction of TRBC1 shows much promise for improving the diagnosis of T-cell neoplasms in the clinical flow laboratory. Most laboratories considering this marker already have existing panels designed for T-cell workups and will be determining how best to incorporate TRBC1. We present this comprehensive summary of TRBC1 and supplemental case examples to familiarize the flow cytometry community with its potential for routine application, provide examples of how to incorporate it into T-cell panels, and signal caution in interpreting the results in certain diagnostic scenarios where appropriate.

Journal Title

Cytometry. Part B, Clinical cytometry

Volume

106

Issue

3

First Page

192

Last Page

202

MeSH Keywords

Flow Cytometry; Humans; T-Lymphocytes; Immunophenotyping; Biomarkers, Tumor

Keywords

T‐cell; flow cytometry; leukemia; lymphoma; validation

Comments

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Publisher's Link: https://onlinelibrary.wiley.com/doi/10.1002/cyto.b.22175

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