Document Type

Article

Publication Date

7-1-2024

Identifier

DOI: 10.34067/KID.0000000000000462

Abstract

Background: Mental health disorders within the pediatric CKD population are prevalent. The frequency is unknown with which psychotropic medications that commonly treat these conditions are used in this population.

Methods: Data from the CKD in Children (CKiD) cohort study were used to describe the use of psychotropic medications and patient-related characteristics of use. Medications were classified into three groups: antidepressants, central nervous system (CNS) stimulants, and antipsychotic/mood stabilizing medications. Participant age, sex, CKD severity, and duration of medication use were ascertained. Medication use was evaluated in parallel with CKD disease type, presence of urological comorbidity, and hypertension. Chi-square tests compared subgroup medication use.

Results: Among 1074 CKiD participants (median baseline age 9.8 years), 6% (n560) used psychotropic medications at study entry with 11% reporting incident use of any medication category (n5120). CNS stimulants were most common at baseline. Antidepressants were more frequent among incident users at 7%. Use of two or more medications was rare (3%). Median eGFR at medication initiation was 45 ml/min per 1.73 m2. CNS stimulants were reported at a higher rate in male compared with female participants (P , 0.05).

Conclusions: Eleven percent of CKiD patients report incident use of any psychotropic medication, with 7% reporting incident use of antidepressants. Future work is warranted to better ascertain the frequency, safety, and efficacy of psychotropic medication usage in relationship to formal mental health disorder diagnoses in the pediatric CKD population.

Journal Title

Kidney360

Volume

5

Issue

7

First Page

967

Last Page

973

MeSH Keywords

Humans; Child; Psychotropic Drugs; Renal Insufficiency, Chronic; Adolescent; Female; Male; Cohort Studies; Child, Preschool

Keywords

Psychotropic Drugs; Chronic Renal Insufficiency; Cohort Studies

Comments

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited.

Publisher's Link: https://journals.lww.com/kidney360/fulltext/2024/07000/psychotropic_medication_usage_in_pediatric_ckd_.9.aspx

Download

Share

COinS