Document Type
Article
Publication Date
8-19-2024
Identifier
DOI: 10.1186/s12882-024-03705-9; PMCID: PMC11334345
Abstract
BACKGROUND: Complications of prolonged continuous kidney replacement therapy (CKRT) have not been well described. Our objective was to describe mineral metabolism and bone findings in children who required prolonged CKRT.
METHODS: In this single center prospective observational study, we enrolled 37 patients who required CKRT for ≥ 28 days with regional citrate anticoagulation. Exposure was duration on CKRT and outcomes were 25-hydroxy vitamin D and osteopenia and/or fractures.
RESULTS: The prevalence of vitamin D deficiency and insufficiency was 17.2% and 69.0%, respectively. 29.7% of patients had radiographic findings of osteopenia and/or fractures. There was no association between vitamin D deficiency or insufficiency with age or ethnicity. Time on CKRT and intact PTH levels were not predictive of vitamin D levels. Children with chronic liver disease were more likely to have osteopenia and/or fractures compared children with other primary diagnoses, odds ratio (3.99 (95%CI, 1.58-2.91), p = 0.003) after adjusting for age and time on CKRT.
CONCLUSION: Vitamin D deficiency and/or insufficiency, and osteopenia and/or fractures are prevalent among children who require CKRT for a prolonged period. The risk for MBD may be higher with chronic liver disease. Higher doses of vitamin D may be required to maintain normal levels while on CKRT.
Journal Title
BMC nephrology [electronic resource]
Volume
25
Issue
1
First Page
265
Last Page
265
MeSH Keywords
Humans; Female; Male; Bone Diseases, Metabolic; Prospective Studies; Vitamin D Deficiency; Child; Vitamin D; Child, Preschool; Adolescent; Continuous Renal Replacement Therapy; Fractures, Bone; Prevalence
Keywords
Metabolic Bone Diseases; Prospective Studies; Vitamin D Deficiency; Vitamin D; Continuous Renal Replacement Therapy; Bone Fractures; Prevalence
Recommended Citation
Imani PD, Vega M, Pekkucuksen NT, Srivaths P, Arikan AA. Vitamin D and metabolic bone disease in prolonged continuous kidney replacement therapy: a prospective observational study. BMC Nephrol. 2024;25(1):265. Published 2024 Aug 19. doi:10.1186/s12882-024-03705-9
Comments
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Publisher's Link: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-024-03705-9