Document Type
Article
Publication Date
9-2026
Identifier
DOI: 10.1308/rcsann.2026.0019; PMCID: PMC13529390
Abstract
INTRODUCTION: Congenitally corrected transposition of the great arteries (ccTGA) is a rare disorder. Here, we evaluated the effectiveness of physiological, anatomical and Fontan repair techniques for ccTGA.
METHODS: A systematic database search in PubMed, Embase and Cochrane Central Register of Controlled Trials was conducted from inception to 5 June 2023. Random-effects network meta-analysis was performed, comparing mortality, postoperative arrhythmias, reintervention after definitive surgery and transplant-free survival in patients undergoing physiological, anatomical and Fontan repair.
FINDINGS: A total of 1,209 patients were included from nine studies. Fontan repair was associated with a higher rate of transplant-free survival (absolute risk [AR] 0.999 (±0.0101), 95% confidence interval [CI]) and reintervention after definitive surgery (AR 0.098 (±0.067), 95% CI), whereas the difference for mortality and postoperative arrhythmias did not reach statistical significance.
CONCLUSIONS: Fontan repair is significantly better than anatomical or physiological repair in terms of transplant-free survival and also had a better rank probability for overall survival and reintervention after definitive surgery.
Journal Title
Annals of the Royal College of Surgeons of England
Volume
108
Issue
7
First Page
510
Last Page
517
MeSH Keywords
Humans; Congenitally Corrected Transposition of the Great Arteries; Fontan Procedure; Postoperative Complications; Reoperation; Treatment Outcome
PubMed ID
41782460
Keywords
Abnormality; Cardiac surgery; Congenital, transposition of the great vessels; Congenitally corrected; Congenitally corrected, transposition of the great arteries; Heart transplantation
Recommended Citation
Hasan SU, Usmani S, Ahmed SH, et al. Outcomes for congenitally corrected transposition of great arteries using various surgical techniques: a systematic review and network meta-analysis. Ann R Coll Surg Engl. 2026;108(7):510-517. doi:10.1308/rcsann.2026.0019
Comments
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, reproduction, and adaptation in any medium, provided the original work is properly attributed.
Publisher's Link: https://doi.org/10.1308/rcsann.2026.0019