Effect of donor ethnicity on kidney survival in different recipient pairs: an analysis of the OPTN/UNOS database.

Creator(s)

C O. Callender
W S. Cherikh
P Traverso
A Hernandez
Tolulope A. Oyetunji, Children's Mercy HospitalFollow
D Chang

Document Type

Article

Publication Date

12-1-2009

Identifier

PMCID: PMC2826243, DOI: 10.1016/j.transproceed.2009.06.182

Abstract

BACKGROUND: Previous multivariate analysis performed between April 1, 1994, and December 31, 2000 from the Organ Procurement Transplant Network/United Network for Organ Sharing (OPTN/UNOS) database has shown that kidneys from black donors were associated with lower graft survival. We compared graft and patient survival of different kidney donor-to-recipient ethnic combinations to see if this result still holds on a recent cohort of US kidney transplants.

METHODS: We included 72,495 recipients of deceased and living donor kidney alone transplants from 2001 to 2005. A multivariate Cox regression method was used to analyze the effect of donor-recipient ethnicity on graft and patient survival within 5 years of transplant, and to adjust for the effect of other donor, recipient, and transplant characteristics. Results are presented as hazard ratios (HR) with the 95% confidence limit (CL) and P values.

RESULTS: Adjusted HRs of donor-recipient patient survival were: white to white (1); and white to black (1.22; P = .001). Graft survival HRs were black to black (1.40; P

SUMMARY: Black donor kidneys are associated with significantly lower graft survival when transplanted into whites or blacks and are only associated with lower patient survival when these kidneys are transplanted into white recipients. The graft and patient survival rates for Asian and Latino/Hispanic recipients, however, were not affected by donor ethnicity. This analysis underscores the need for research to better understand the reasons for these disparities and how to improve the posttransplant graft survival rates of black kidney recipients.

Journal Title

Transplantation proceedings

Volume

41

Issue

10

First Page

4125

Last Page

4130

MeSH Keywords

African Continental Ancestry Group; Asian Continental Ancestry Group; Cadaver; Continental Population Groups; Ethnic Groups; European Continental Ancestry Group; Graft Survival; Hispanic Americans; Humans; Kidney Transplantation; Living Donors; Multivariate Analysis; Odds Ratio; Regression Analysis; Time Factors; Tissue Donors; Tissue and Organ Procurement

Keywords

Kidneys; Transplant; Donation; Race; Ethnic Groups; Outcomes

Comments

Grant support

• P20 MD000512-04/MD/NIMHD NIH HHS/United States

Link to publisher's version:
https://www.sciencedirect.com/science/article/pii/S0041134509013086?via%3Dihub

Recommended Citation

Callender, C. O., Cherikh, W. S., Traverso, P., Hernandez, A., Oyetunji, T. A., Chang, D. Effect of donor ethnicity on kidney survival in different recipient pairs: an analysis of the OPTN/UNOS database. Transplantation proceedings 41, 4125-4130 (2009).