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Download Sepsis PICU Algorithm (208 KB)

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Download Sepsis ED Algorithm (260 KB)

Download Sepsis ED Supporting Materials (3.8 MB)

Publication Date



These guidelines do not establish a standard of care to be followed in every case. It is recognized that each case is different and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare guidelines for each. Accordingly, these guidelines should guide care with the understanding that departures from them may be required at times.

Objective of the Clinical Pathway

The objective of the Sepsis Care Process Model (CPM) is to provide care standards for the infant or child with suspected sepsis, sepsis, or septic shock. The Sepsis CPM provides guidance regarding recommended evaluation, treatment, and reassessment to minimize variation in care.

Target Users

Physicians (Emergency Department, Critical Care Medicine, Urgent Care, Neonatology, Hospital Medicine, Infectious Diseases, Hematology/Oncology, Fellows, Resident Physicians, Community Physicians); Nurse Practitioners; Nurses; Pharmacy




Care Process Models (CPMs) promote evidence based, safe, and high-value care for patients with common or high-risk clinical conditions when national or international guidelines are not available or applicable. CPMs are informed by methodical review of scientific literature and the consensus of a multidisciplinary committee of subject matter experts and key stakeholders at Children’s Mercy Kansas City. Processes within CPMs may be specific to Children’s Mercy Kansas City and should be evaluated before applying to a different setting.

Care Process Models are updated on a revision schedule. Primary files will always be the most current update. Previous revisions are available upon request from Children’s Mercy Library Services.

Finalized April 2017; Revised June 2023, February 2024


Included in

Pediatrics Commons