Title

Kawasaki disease and immunisation: A systematic review.

Document Type

Article

Publication Date

3-27-2017

Identifier

DOI: 10.1016/j.vaccine.2016.09.033

Abstract

BACKGROUND: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation.

METHODS: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature.

RESULTS: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging.

CONCLUSIONS: Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.

Journal Title

Vaccine

Volume

35

Issue

14

First Page

1770

Last Page

1779

MeSH Keywords

Humans; Immunization; Mucocutaneous Lymph Node Syndrome; Risk; Vaccination; Vaccines

Keywords

Adverse event; Case definition; Guidelines; Immunization; Kawasaki disease; Systematic review

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