Kawasaki disease and immunisation: A systematic review.
BACKGROUND: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation.
METHODS: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature.
RESULTS: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging.
CONCLUSIONS: Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.
Humans; Immunization; Mucocutaneous Lymph Node Syndrome; Risk; Vaccination; Vaccines
Adverse event; Case definition; Guidelines; Immunization; Kawasaki disease; Systematic review
Phuong, Linny Kimly; Bonetto, Caterina; Buttery, Jim; Pernus, Yolanda Brauchli; Chandler, Rebecca; Felicetti, Patrizia; Goldenthal, Karen L.; Kucuku, Merita; Monaco, Giuseppe; Pahud, Barbara A.; Shulman, Stanford T.; Top, Karina A.; Trotta, Francesco; Ulloa-Gutierrez, Rolando; Varricchio, Frederick; de Ferranti, Sarah; Newburger, Jane W.; Dahdah, Nagib; Singh, Surjit; Bonhoeffer, Jan; Burgner, David; and Brighton Collaboration Kawasaki Disease (KD) Working Group, "Kawasaki disease and immunisation: A systematic review." (2017). Manuscripts, Articles, Book Chapters and Other Papers. 1105.