Kawasaki disease and immunisation: A systematic review.
BACKGROUND: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation.
METHODS: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature.
RESULTS: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging.
CONCLUSIONS: Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.
Humans; Immunization; Mucocutaneous Lymph Node Syndrome; Risk; Vaccination; Vaccines
Adverse event; Case definition; Guidelines; Immunization; Kawasaki disease; Systematic review
Phuong LK, Bonetto C, Buttery J, et al. Kawasaki disease and immunisation: A systematic review. Vaccine. 2017;35(14):1770-1779. doi:10.1016/j.vaccine.2016.09.033