PMCID: PMC5518633 DOI: 10.1161/HYPERTENSIONAHA.117.09475
Hypertension and blood pressure variability (BPV; SD and average real variability) in primary proteinuric glomerulopathies are not well described. Data were from 433 participants in the NEPTUNE (Nephrotic Syndrome Study Network). Hypertensive BP status was defined as previous history of hypertension or BP ≥140/90 mm Hg for adults/≥95th percentile for children at baseline. BPV was measured in participants with ≥3 visits in the first year. Two-hundred ninety-six adults (43 years [interquartile range, 32-57.8 years], 61.5% male) and 147 children (11 years [interquartile range, 5-14 years], 57.8% male) were evaluated. At baseline, 64.8% of adults and 46.9% of children were hypertensive. Histological diagnosis was associated with hypertensive status in adults (P=0.036). In adults, hypertensive status was associated with lower hazard of complete remission (hazard ratio, 0.36; 95% confidence interval, 0.19-0.68) and greater hazard of achieving the composite end point (end-stage renal disease or estimated glomerular filtration rate decline >40%; hazard ratio, 4.1; 95% confidence interval, 1.4-12). Greater systolic and diastolic SD and average real variability were also associated with greater hazard of reaching the composite end point in adults (all PP
Adolescent; Adult; Ambulatory Care; Blood Pressure; Blood Pressure Determination; Child; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertension, Malignant; Male; Middle Aged; Nephrotic Syndrome; Observer Variation; Outcome and Process Assessment (Health Care); Prognosis; Proportional Hazards Models; Risk Factors; United States
adult; blood pressure; hypertension; nephrotic syndrome; prevalence
Sethna, C. B., Meyers, K. E., Mariani, L. H., Psoter, K. J., Gadegbeku, C. A., Gibson, K. L., Srivastava, T., Kretzler, M., Brady, T. M. Blood Pressure and Visit-to-Visit Blood Pressure Variability Among Individuals With Primary Proteinuric Glomerulopathies. Hypertension 70, 315-323 (2017).