Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity.
A child with malaria from a chloroquine-resistant area received an accidental overdose of chloroquine administered by a parent. Application of pharmacokinetics permitted definitive treatment with mefloquine in a safe and effective manner.
The Pediatric infectious disease journal
Antimalarials; Child; Chloroquine; Drug Overdose; Drug Synergism; Drug Therapy, Combination; Humans; Malaria; Male; Mefloquine
Lowry, J A.; Corry, A; Fitzmaurice, Laura; Jackson, Mary Anne; and Kearns, G L., "Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity." (2001). Manuscripts, Articles, Book Chapters and Other Papers. 1289.