Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity.
A child with malaria from a chloroquine-resistant area received an accidental overdose of chloroquine administered by a parent. Application of pharmacokinetics permitted definitive treatment with mefloquine in a safe and effective manner.
The Pediatric infectious disease journal
Antimalarials; Child; Chloroquine; Drug Overdose; Drug Synergism; Drug Therapy, Combination; Humans; Malaria; Male; Mefloquine
Lowry, J. A., Corry, A., Fitzmaurice, L., Jackson, M., Kearns, G. L. Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity. The Pediatric infectious disease journal 20, 223-224 (2001).