Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results.
PMCID: PMC6511296; DOI: 10.1016/j.bbmt.2018.12.765
Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors ageAmerica, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation. Both older age (age 13 to 17 years versus younger) and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57% with grade 2-4 pain and 17% with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age(P20% of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplantation; Peripheral Blood Stem Cell Transplantation; Tissue Donors; Pain, Procedural; Female; Adolescent; Male
BM collection toxicities; Donor safety; PBSC collection toxicities; Stem cell transplantation
Pulsipher, M. A., Logan, B. R., Kiefer, D. M., Chitphakdithai, P., Riches, M. L., Rizzo, J. D., Anderlini, P., Leitman, S. F., Varni, J. W., Kobusingye, H., Besser, R. M., Miller, J. P., Drexler, R. J., Abdel-Mageed, A., Ahmed, I. A., Ball, E. D., Bolwell, B. J., Bunin, N. J., Cheerva, A., Delgado, D. C., Dvorak, C. C., Gillio, A. P., Hahn, T. E., Hale, G. A., Haight, A. E., Hayes-Lattin, B. M., Kasow, K. A., Linenberger, M., Magalhaes-Silverman, M., Mori, S., Prasad, V. K., Quigg, T. C., Sahdev, I., Schriber, J. R., Shenoy, S., Tse, W. T., Yanik, G. A., Navarro, W. H., Horowitz, M. M., Confer, D. L., Shaw, B. E., Switzer, G. E. Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 25, 955-964 (2019).