Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections.
PMCID: PMC6309646 [Available on 2020-01-01] DOI: 10.1016/j.jpeds.2018.08.066
OBJECTIVE: To determine factors associated with adverse outcomes among febrile young infants with invasive bacterial infections (IBIs) (ie, bacteremia and/or bacterial meningitis).
STUDY DESIGN: Multicenter, retrospective cohort study (July 2011-June 2016) of febrile infants ≤60 days of age with pathogenic bacterial growth in blood and/or cerebrospinal fluid. Subjects were identified by query of local microbiology laboratory and/or electronic medical record systems, and clinical data were extracted by medical record review. Mixed-effect logistic regression was employed to determine clinical factors associated with 30-day adverse outcomes, which were defined as death, neurologic sequelae, mechanical ventilation, or vasoactive medication receipt.
RESULTS: Three hundred fifty infants met inclusion criteria; 279 (79.7%) with bacteremia without meningitis and 71 (20.3%) with bacterial meningitis. Forty-two (12.0%) infants had a 30-day adverse outcome: 29 of 71 (40.8%) with bacterial meningitis vs 13 of 279 (4.7%) with bacteremia without meningitis (36.2% difference, 95% CI 25.1%-48.0%; P < .001). On adjusted analysis, bacterial meningitis (aOR 16.3, 95% CI 6.5-41.0; P < .001), prematurity (aOR 7.1, 95% CI 2.6-19.7; P < .001), and ill appearance (aOR 3.8, 95% CI 1.6-9.1; P = .002) were associated with adverse outcomes. Among infants who were born at term, not ill appearing, and had bacteremia without meningitis, only 2 of 184 (1.1%) had adverse outcomes, and there were no deaths.
CONCLUSIONS: Among febrile infants ≤60 days old with IBI, prematurity, ill appearance, and bacterial meningitis (vs bacteremia without meningitis) were associated with adverse outcomes. These factors can inform clinical decision-making for febrile young infants with IBI.
The Journal of pediatrics
Anti-Bacterial Agents; Bacteremia; Cohort Studies; Female; Fever; Humans; Infant; Infant Mortality; Infant, Newborn; Male; Meningitis, Bacterial; Retrospective Studies; Risk Factors
bacteremia; bacterial meningitis; prematurity
Pruitt, Christopher M.; Neuman, Mark I.; Shah, Samir S.; Shabanova, Veronika; Woll, Christopher; Wang, Marie E.; Alpern, Elizabeth R.; Williams, Derek J.; Sartori, Laura; Desai, Sanyukta; Leazer, Rianna C.; Marble, Richard D.; McCulloh, Russell J.; DePorre, Adrienne G.; Rooholamini, Sahar N.; Lumb, Catherine E.; Balamuth, Fran; Shin, Sarah; Aronson, Paul L.; and Febrile Young Infant Research Collaborative, "Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections." (2019). Manuscripts, Articles, Book Chapters and Other Papers. 1335.