Early Initiation of Diabetes Devices Relates to Improved Glycemic Control in Children with Recent-Onset Type 1 Diabetes Mellitus.
DOI: 10.1089/dia.2019.0026; PMCID: PMC6602098 (available on 2020-07-01)
Objective: To test whether the addition of an insulin pump or continuous glucose monitor (CGM) related to reduced glycated hemoglobin A1c (HbA1c) in large cohort of children, 5-9 years old, and within 1 year of their type 1 diabetes (T1D) diagnosis. Research Design and Methods: The study uses data from families of children with recent-onset T1D and who were between 5 and 9 years old. Study analyses used children's HbA1c values at baseline and at the 6-month follow-up. Parents reported on family demographics and children's T1D device use in their daily management (e.g., insulin pump or CGM). Children's mean T1D duration was 4.70 ± 3.28 months at baseline, so the 6-month assessment point was ∼12 months postdiagnosis. Results: One hundred-eleven families participated. At baseline, child mean age was 7.51 ± 1.37 years, and mean child HbA1c was 7.65% ± 1.40%. In addition, 17% of children used an insulin pump, and 17.1% of children used CGM. Six months later, 35.1% of children had started an insulin pump and 25.2% had started CGM. Repeated measures analyses of variance results showed a smaller overall HbA1c between baseline and 6 months for children using an insulin pump versus children not on a pump. For CGM, results showed that children starting a CGM during this window had a significantly lower HbA1c level than children who had not started on CGM. Conclusions: The study results suggest that early initiation of either an insulin pump or CGM in children newly diagnosed with T1D may help to improve child HbA1c levels within the first 12 months of diabetes.
Diabetes technology & therapeutics
Blood Glucose Self-Monitoring; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin A; Humans; Hypoglycemic Agents; Insulin; Insulin Infusion Systems; Male; Time Factors; Treatment Outcome
Continuous glucose monitoring; Continuous subcutaneous insulin infusion; HbA1c; New onset; Pediatrics; Type 1 diabetes
Patton, S. R., Noser, A., Youngkin, E., Majidi, S., Clements, M. A. Early Initiation of Diabetes Devices Relates to Improved Glycemic Control in Children with Recent-Onset Type 1 Diabetes Mellitus. Diabetes technology & therapeutics 21, 379-384 (2019).