Title
Higher eGFR at Dialysis Initiation Is Not Associated with a Survival Benefit in Children.
Document Type
Article
Publication Date
8-2019
Identifier
DOI: 10.1681/ASN.2018111130; PMCID: PMC6683704 (available on 2020-08-01)
Abstract
BACKGROUND: Study findings suggest that initiating dialysis at a higher eGFR level in adults with ESRD does not improve survival. It is less clear whether starting dialysis at a higher eGFR is associated with a survival benefit in children with CKD.
METHODS: To investigate this issue, we performed a retrospective cohort study of pediatric patients aged 1-18 years who, according to the US Renal Data System, started dialysis between 1995 and 2015. The primary predictor was eGFR at the time of dialysis initiation, categorized as higher (eGFR>10 ml/min per 1.73 m
RESULTS: Of 15,170 children, 4327 (29%) had a higher eGFR (median eGFR, 12.8 ml/min per 1.73 m
CONCLUSIONS: In children with ESRD, a higher eGFR at dialysis initiation is associated with lower survival, particularly among children whose initial treatment modality is hemodialysis.
Journal Title
Journal of the American Society of Nephrology : JASN
Volume
30
Issue
8
First Page
1505
Last Page
1513
MeSH Keywords
Adolescent; Child; Child, Preschool; Creatinine; Female; Glomerular Filtration Rate; Humans; Infant; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Peritoneal Dialysis; Renal Dialysis; Retrospective Studies; Treatment Outcome; United States
Keywords
ESRD; dialysis; pediatric nephrology
Recommended Citation
Winnicki, E., Johansen, K. L., Cabana, M. D., Warady, B. A., McCulloch, C. E., Grimes, B., Ku, E. Higher eGFR at Dialysis Initiation Is Not Associated with a Survival Benefit in Children. Journal of the American Society of Nephrology : JASN 30, 1505-1513 (2019).
Comments
Grant support